Accidental Overdose of Multiple Chemotherapeutic Agents

Accidental Overdose of Multiple Chemotherapeutic Agents

A 35-year-old man with refractory low grade diffuse centroblastic centrocytic non-Hodgkin's lymphoma was treated accidentally with an overdose of multiple chemotherapeutic agents. He was given adriamycin 50 mg/m2 and cyclophosphamide 350 mg/m2 for 6 days followed by 4 days of vincristine 1 mg/m2 and bleomycin 10 mg/m2. He was transferred when he developed pancytopenia, fever, severe mucositis, ...

Accidental intrathecal methotrexate overdose.

Re: Treatment of accidental intrathecal methotrexate overdose.

Widemann et al. (1) presented data on the use of cerebrospinal fl uid (CSF) exchange to remove methotrexate before carboxypeptidase G 2 (CPDG 2) administration among patients who had an accidental intrathecal methotrexate overdose. They reported that CSF drainage removed 32% – 58% of the methotrexate dose. Although they showed the percent decreases in CSF methotrexate concentration before and a...

Providing health education on accidental drug overdose.

There is an association between intravenous drug use and increased risk of death due to overdose. This article reports on the evaluation of a health promotion programme to educate drug users on preventing an overdose and how to deal with an overdose if it occurs.

Recovery from blindness following accidental quinine overdose

CASE A 46-year-old woman presented with sudden loss of vision in both eyes, apparent since waking. She also complained of partial hearing loss. The previous evening she had experienced difficulty sleeping due to (long-standing) restless legs and had self-medicated with quinine, taking an accidental overdose of 1.8 g. On admission, she was alert but unable to perceive light in either eye, and ha...